Beef & Cheese Enchilada Casserole – our go-to Mexican casserole! Cheesy quesadillas smothered in beefy enchilada sauce and cheese. Everyone cleaned their plate and went back for seconds!! Ground beef, taco seasoning, Rotel, enchilada sauce, cream cheese, pepper jack cheese, low-carb tortillas, and Mexican cheese blend. Great flavor and so easy to make! Top with your favorite taco toppings for a meal better than any restaurant.

plate of enchiladas with baking dish in the background

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Easy Mexican Casserole

This Beef & Cheese Enchilada Casserole is a family favorite! Cheesy quesadillas smothered in beefy enchilada sauce and more cheese. YASSS!!! One bite and you will be blown away. This is comfort food at its best. Top the casserole with your favorite taco toppings and enjoy!

The best part about this recipe is that it is super easy to make low-carb and keto-friendly with low-carb tortillas and low-carb enchilada sauce. We aren't on a low-carb or keto diet, but we always make the low-carb version of this casserole. It tastes great and saves on calories too!

enchilada on a spatula in a baking dish

How to Make Beef & Cheese Enchilada Casserole

This casserole is easy to make with only a few simple ingredients. Start with browning some ground beef in a skillet. Drain the fat. Add a packet of taco seasoning and water. Simmer until the liquid is absorbed. Add a can of enchilada sauce and Rotel diced tomatoes and green chiles. Simmer for 5 minutes. Remove from heat. Spread half of the sauce in the bottom of a baking dish.

Spread cream cheese on top of small flour tortillas. Top the cream cheese with shredded cheese. Fold tortillas in half. Place folded tortillas on top of the meat sauce; pour remaining sauce over the top of the tortillas. Top the sauce with more shredded cheese. Cover with aluminum foil and bake for 20 to 25 minutes.

  • I use La Banderita Snack Size Low-Carb flour tortillas in this dish.
    • You can use any tortilla that you prefer. Flour or corn both work fine.
  • For a low-carb dish, use a low-carb enchilada sauce. Look for sauces with no sugar added such as Rosarita Enchilada Sauce, El Pato, or La Victoria Enchilada Sauce.
  • I use a Mexican cheese blend in the tortillas. Feel free to use any cheese that you enjoy. Cheddar, Monterey Jack, or pepper jack cheese are all delicious.
  • Here is our recipe for Homemade Taco Seasoning: https://www.plainchicken.com/homemade-taco-seasoning/
  • Feel free to add vegetables to the tortillas – onions, peppers, diced green chiles, tomatoes, corn, black beans are all great.
  • Is Beef & Cheese Enchilada Casserole spicy? We did not think this dish was spicy. If you are worried about the heat, use a can of MILD Rotel diced tomatoes and green chiles or a can of plain diced tomatoes.
  • For a lower calorie option, substitute ground turkey.
plate of beef enchiladas topped with sour cream and salsa

What to Serve with Beef Enchilada Bake

This casserole is always a hit. SO much better than the Mexican restaurant!! We like to top the casserole with sour cream, salsa, and green onions. To really jazz this up, drizzle it with some of our Jalapeño Ranch Dip. YUM! We serve this tortilla bake with black beans and/or rice. For a low-carb side dish, try our Southwestern Green Beans. Add this to your menu ASAP. You won't be disappointed!

Looking for more side dish ideas? Here are a few of our favorite recipes from the blog that go great with this Mexican casserole:

Dip

The ULTIMATE Queso

The ULTIMATE Queso – the BEST cheese dip EVER! Creamy Rotel Dip loaded with sausage and chili beans. Can make…

Vegetables

Southwestern Green Bean Casserole

Southwestern Green Bean Casserole – perfect holiday side! A southwestern take on a traditional recipe. Green beans, cream of mushroom…

Mexican

Mexican Street Corn Casserole

Mexican Street Corn Casserole – all the flavors of Mexican street corn but requires no flossing after eating! Corn, mayonnaise,…

Side Dish

Pepper Jack Rice Bake

Pepper Jack Rice Bake – CRAZY good!! Cooked rice loaded with onions, red bell pepper, green chiles, corn, cream of…

scooping enchiladas from a baking dish

Beef & Cheese Enchilada Casserole

Yield: 6 people

Prep Time 15 mins

Cook Time 20 mins

Total Time 35 mins

Beef & Cheese Enchilada Casserole – our go-to Mexican casserole! Cheesy quesadillas smothered in beefy enchilada sauce and cheese. Everyone cleaned their plate and went back for seconds!! Ground beef, taco seasoning, Rotel, enchilada sauce, cream cheese, pepper jack cheese, low-carb tortillas, and Mexican cheese blend. Great flavor and so easy to make! Top with your favorite taco toppings for a meal better than any restaurant.

  • 1¼ lb ground beef
  • 1 (1-oz) packet taco seasoning
  • ½ cup water
  • 1 (10-oz) can enchilada sauce
  • 1 (10-oz) can Rotel tomatoes and diced green chiles, undrained
  • 12 (6-inch) flour tortillas
  • 6- oz cream cheese
  • 2 cups shredded Mexican cheese blend

  • Preheat oven to 350ºF. Lightly spray a 9×13-inch baking dish with cooking spray. Set aside.

  • Brown the ground beef in a skillet. Drain fat. Add a packet of taco seasoning and water. Simmer until the liquid is absorbed, about 5 minutes.

  • Add a can of enchilada sauce and Rotel diced tomatoes and green chiles to the skillet. Simmer for 5 minutes. Remove from heat. Spread half of the sauce in the bottom of a baking dish.

  • Spread cream cheese on top of small flour tortillas. Top the cream cheese with 2 cups of shredded cheese. Fold tortillas in half. Place folded tortillas on top of the meat sauce; pour remaining sauce over the top of the tortillas. Sprinkle the remaining cup of cheese on top of the sauce.

  • Cover and bake for 20 to 25 minutes.

low carb tortillas

  • I use La Banderita Snack Size Low-Carb flour tortillas in this dish.
    • You can use any tortilla that you prefer. Flour or corn both work fine.
  • For a low-carb dish, use a low-carb enchilada sauce. Look for sauces with no sugar added such as Rosarita Enchilada Sauce, El Pato, or La Victoria Enchilada Sauce.
  • I use a Mexican cheese blend in the tortillas. Feel free to use any cheese that you enjoy. Cheddar, Monterey Jack, or pepper jack cheese are all delicious.
  • Here is our recipe for Homemade Taco Seasoning: https://www.plainchicken.com/homemade-taco-seasoning/
  • Feel free to add vegetables to the tortillas – onions, peppers, diced green chiles, tomatoes, corn, black beans are all great.
  • Is Beef & Cheese Enchilada Casserole spicy? We did not think this dish was spicy. If you are worried about the heat, use a can of MILD Rotel diced tomatoes and green chiles or a can of plain diced tomatoes.
  • For a lower calorie option, substitute ground turkey.

Steph

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plate of enchiladas topped with sour cream and salsa